The Effects of Ristocetin and von Willebrand Factor on Platelet Electrophoretic Mobility
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چکیده
منابع مشابه
The effects of ristocetin and von Willebrand factor on platelet electrophoretic mobility.
Ristocetin will induce the agglutination of platelets in the presence of von Willebrand factor. In previous studies, an electrostatic mechanism was proposed for this phenomenon wherein first the platelet's surface charge is reduced by the binding of ristocetin and then the von Willebrand factor acts as a bridge between platelets. To test this hypothesis, the effects of ristocetin and von Willeb...
متن کاملPlatelet-collagen interaction: inhibition by ristocetin and enhancement by von Willebrand factor-platelet binding.
The contribution of von Willebrand factor (vWF)-platelet binding to platelet-collagen interaction was examined in vitro. The binding of vWF to platelets was mediated and regulated by ristocetin. Subthreshold concentrations of ristocetin (less than or equal to 1 mg/mL), insufficient to cause ristocetin-induced platelet aggregation (RIPA), were added to platelet-rich plasma (PRP) prior to the add...
متن کاملAbnormalities of Factor VIII and Platelet Aggregation-Use of Ristocetin in Diagnosing the von Willebrand Syndrome
Ristocetin was used to study platelet aggregation in platelet-rich plasma and to assay the von Willebrand factor activity of factor VIII (Vlll,, ). Ristocetin-induced platelet aggregation (RIPA) was decreased in 13 of 18 patients with von Willebrand’s disease (VWD) who had decreased plasma levels of Vlll ,. The five patients with normal RIPA appeared to have mild VWD but did not constitute a se...
متن کاملAbnormalities of Factor VIII and Platelet Aggregation-Use of Ristocetin in Diagnosing the von Willebrand Syndrome
Ristocetin was used to study platelet aggregation in platelet-rich plasma and to assay the von Willebrand factor activity of factor VIII (Vlll,, ). Ristocetin-induced platelet aggregation (RIPA) was decreased in 13 of 18 patients with von Willebrand’s disease (VWD) who had decreased plasma levels of Vlll ,. The five patients with normal RIPA appeared to have mild VWD but did not constitute a se...
متن کاملAbnormalities of Factor VIII and Platelet Aggregation-Use of Ristocetin in Diagnosing the von Willebrand Syndrome
Ristocetin was used to study platelet aggregation in platelet-rich plasma and to assay the von Willebrand factor activity of factor VIII (Vlll,, ). Ristocetin-induced platelet aggregation (RIPA) was decreased in 13 of 18 patients with von Willebrand’s disease (VWD) who had decreased plasma levels of Vlll ,. The five patients with normal RIPA appeared to have mild VWD but did not constitute a se...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1978
ISSN: 0021-9738
DOI: 10.1172/jci109032